Endocrine Abstracts

Background: Diabetic striatopathy (DS) is a rare dyskinetic syndrome associated with acute decompensated hyperglycemia that commonly presents as hemichorea-ballism. Its natural history following resolution of the hyperglycemic crisis is not well delineated.Methods: The study was a prospective evaluation of the long-term clinico-radiological outcomes of patients presenting with DS. Neuroimaging (CT/MRI) was performed at baseline and follow-up (>3 mont...

Objective: The primary objective was to characterise the paracrine milieu in three subjects with apparently idiopathic gigantomastia and to study the relative expression of implicated factors in these pathological specimens as compared to tissue samples from normal breast, gynecomastia and breast cancer.Background: Gigantomastia refers to pathological breast enlargement usually occurring in the peripubertal or peripartum period. Idiopathic gigantomastia,...

Introduction: Nelson’s syndrome is a significant long-term complication of bilateral adrenalectomy for Cushing’s disease. However, evidence about possible factors that can predict its occurrence, is controversial and limited.Objective: The objective of this analysis was to elucidate the role of various factors in prediction of Nelson’s syndrome and the extent of their modifying effect.Methods: All patients with Cushi...

Context: Serum IGF-binding protein-3 (IGFBP-3) and molar IGF-I to IGFBP-3 ratio can aid the diagnosis of GH-related diseases. However, their clinical utility is limited by lack of validated reference intervals.Objectives: To establish age-, gender- and Tanner stage-specific reference intervals for IGFBP-3 and IGF-I to IGFBP-3 ratio for Indian ethnicity.Setting and Participants: We conducted a cross-sectional epidemiological study (...

Context: To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.Objectives: To generate normative IGF-I data for chronological age, bone age (BA) [Greulich & Pyle] and Tanner stage for both genders.Setting and Participants: We conducted a cross-sectional epidemiological study for children (age...

Context: Serum IGF-1 levels are of paramount importance for diagnosis and management of growth related disorders. The reference range of IGF- 1 should be ethnicity and Tanner specific. Indian data on the same is scarce and there is a need to develop the same.Objective: To develop age, sex and Tanner based normative reference range of serum IGF-1 level for Indian children and correlate the same with peri-pubertal hormonal parameters.<p class="abstext"...